Report Description Table of Contents 1. Introduction and Strategic Context The Global Computational Fluid Dynamics ( CFD ) Market is expected to expand at a robust CAGR of 9.6% , reaching an estimated USD 3.9 billion by 2030 , up from around USD 2.2 billion in 2024 , according to Strategic Market Research estimates. CFD is more than just a simulation tool — it’s the engine behind some of the most precise design and optimization decisions across industries. From analyzing how air flows around an electric vehicle, to simulating blood flow in biomedical devices or predicting turbulence in aerospace engineering, CFD has become a silent workhorse in modern innovation pipelines. The market’s momentum is largely driven by a few interconnected forces. First, the digital twin movement has moved from theory to practice — and CFD models often sit at the core of that. Second, industries under regulatory pressure to improve efficiency and sustainability (think aviation, energy, and automotive) are increasingly relying on CFD to simulate performance before committing physical resources. Third, generative design and AI-powered optimization are reshaping engineering — and CFD is now being integrated into iterative, autonomous design loops. There’s also a broader structural change unfolding. Once confined to top-tier engineering firms and academic labs, CFD is becoming democratized. Cloud-based solvers, browser-accessible platforms, and no-code simulation environments are unlocking access for small firms, students, and even early-stage startups. From a stakeholder perspective, the ecosystem is widening. Traditional OEMs in automotive, aerospace, and energy remain the core users — but new demand is coming from electronics cooling, smart infrastructure, climate modeling , and medtech . Investors are showing renewed interest too, especially in platforms that integrate CFD with AI and machine learning. Software vendors like ANSYS , Siemens Digital Industries Software , Dassault Systèmes , and emerging cloud-native challengers are reshaping pricing models, accessibility, and solver complexity. At the same time, public research institutions are pumping out open-source solvers and multiphysics frameworks that challenge proprietary dominance. To be blunt, CFD is no longer a luxury reserved for PhD engineers — it’s becoming foundational across simulation-driven design strategies. The next six years will determine whether CFD can fully scale beyond its traditional strongholds and serve a much wider, interdisciplinary user base. 2. Market Segmentation and Forecast Scope The computational fluid dynamics (CFD) market spans a variety of dimensions — from deployment environments to industries served — each reflecting different levels of complexity, fidelity, and performance requirements. Here’s how the segmentation typically breaks down: By Deployment Mode On-Premise CFD Still the standard for aerospace, automotive, and defense users with stringent data security and high-fidelity requirements. These solutions are preferred when simulation precision and access to full solver libraries outweigh cost and flexibility. Cloud-Based CFD Gaining traction fast, especially in small-to-midsize engineering firms. Browser-based CFD platforms are being adopted for their pay-as-you-go pricing, scalability, and integration with AI-powered design tools. Startups and research institutions also benefit from the reduced IT overhead. In 2024, cloud deployments are estimated to account for around 27% of total CFD revenue — a share expected to double by 2030 as accessibility improves. By Application Area Aerospace & Defense Still the most mature user base. Simulations focus on turbulence modeling , supersonic flow, and combustion. CFD remains mission-critical for aircraft design, missile testing, and thermal shielding. Automotive & Transportation Used for everything from EV battery cooling and cabin airflow to aerodynamic drag optimization. As fuel efficiency and thermal management take center stage, CFD is being embedded early in the vehicle design lifecycle. Energy & Power Generation CFD models combustion, fluid transport, and turbine dynamics in both fossil and renewable setups. Wind farm siting, hydrogen systems, and nuclear reactor safety all rely heavily on CFD. Electronics & Semiconductors Demand for high-performance cooling in compact devices (5G infrastructure, chips, data centers ) is driving the rise of thermal CFD in this segment. Engineers simulate airflow, convection, and component heat dissipation under dynamic loads. Healthcare & Life Sciences An emerging but high-impact segment. CFD supports medical device design, prosthetics, drug delivery modeling , and cardiovascular simulation. Its use is expected to rise sharply due to tighter FDA regulations around digital validation. Aerospace & automotive remain dominant, but electronics cooling and biomedical CFD are gaining relevance — both in revenue and visibility. By End User OEMs & Large Enterprises These organizations typically have in-house CFD teams, customized solvers, and HPC infrastructure. They prioritize solver accuracy, multiphysics integration, and long simulation runs. Engineering Service Providers Consultants and firms offering outsourced simulation support are growing, especially in emerging markets. They often use mid-tier CFD tools and balance fidelity with turnaround time. Academic & Research Institutions They contribute heavily to innovation in solver architecture, meshing algorithms, and turbulence modeling . Open-source tools like OpenFOAM are widely adopted here. Startups & SMEs With limited budgets and minimal CFD expertise, these users gravitate toward cloud-based platforms with guided workflows. This segment is key to driving future volume growth. By Region North America Europe Asia Pacific Latin America Middle East & Africa Scope Note: While this segmentation may appear technical, it also reflects a shift in go-to-market dynamics. CFD is moving from being a specialized, post-design tool to an integrated component in early-phase R&D, production, and compliance strategies. The fastest-growing segments are those where CFD drives operational decisions, not just theoretical modeling . 3. Market Trends and Innovation Landscape The CFD market is being reshaped by a wave of innovation that goes far beyond traditional solvers and turbulence models. What was once the domain of academic labs and heavyweight engineering teams is now undergoing real-time transformation — pushed by cloud computing, AI, and cross-disciplinary integration. AI-Driven Simulation and Optimization Artificial intelligence is no longer just a tool for post-processing CFD results — it’s being embedded into the simulation pipeline itself. Today’s advanced CFD platforms are integrating: Neural networks for turbulence prediction Surrogate modeling for faster design space exploration AI-powered meshing suggestions and boundary condition estimation This reduces simulation runtime from hours to minutes in many cases. In industries like aerospace and energy, where full factorial simulations aren’t feasible, AI-driven optimization is becoming essential. One engineering director put it plainly: “CFD without AI in 2025 will feel like CAD without undo.” Cloud-Native Solvers and API-First Platforms A quiet revolution is underway in how CFD is deployed. Instead of running solvers on expensive workstations or HPC clusters, users can now spin up full simulations in the cloud — complete with autoscaling, remote visualization, and API triggers. Platforms like SimScale , Rescale, and OnScale are pioneering this shift. Their tools allow users to call simulations from generative design platforms or even plug into continuous integration pipelines for iterative optimization. What does that mean in practice? CFD is no longer a standalone event. It’s becoming a dynamic service integrated into broader design and simulation loops. Multi-Physics and Multi-Scale Modeling Modern engineering problems rarely involve a single discipline. That’s why leading CFD providers are investing heavily in multiphysics integration — coupling fluid flow with thermal, structural, electromagnetic, or even chemical models. For example: Automotive engineers simulate fluid-structure interaction in EV battery packs Biomedical developers model blood flow + drug dispersion in arterial systems Electronics firms pair thermal CFD with electromagnetic shielding models Solvers that can switch domains — or run them simultaneously — are gaining share in high-complexity industries. Real-Time CFD and Reduced-Order Models For decades, CFD’s biggest drawback was time. Solvers could take hours or even days to return results. That’s changing fast with reduced-order models (ROMs) and GPU acceleration. These light versions of CFD simulations, trained on full-scale runs, can give instant results with reasonable accuracy. Some firms are embedding real-time CFD feedback into design environments like SolidWorks, NX, and even VR interfaces for collaborative engineering. In critical workflows — like aircraft cockpit ventilation or ICU airflow design — these quick-turn models are being used to make on-the-fly decisions with CFD-grade insight. Open-Source and Solver Democratization Open-source solvers like OpenFOAM and SU2 continue to expand their footprint, especially in academia and emerging markets. Their modular architecture and customization flexibility make them ideal for niche modeling (e.g., urban wind flows or environmental simulation). Meanwhile, vendors are moving toward more transparent solver libraries and hybrid license models. Expect to see more collaboration between proprietary and open-source frameworks in the years ahead. Strategic Partnerships Fueling Innovation M&A and alliances are accelerating this evolution: CFD vendors are acquiring meshing and geometry handling startups Cloud computing providers are investing in simulation-as-a-service Hardware manufacturers are co-developing GPU-accelerated CFD workflows Bottom line: CFD is no longer evolving in isolation . It’s becoming a core layer in the broader digital engineering stack — from simulation-led design to predictive maintenance. 4. Competitive Intelligence and Benchmarking The CFD landscape is led by a mix of legacy software giants and newer, cloud-native disruptors — each bringing distinct strategies to serve a broadening user base. What differentiates players in this space isn’t just solver accuracy — it’s also accessibility, scalability, and how well their tools fit into real-world workflows. ANSYS A dominant force in the CFD world, ANSYS has built its reputation on solver fidelity and multiphysics depth. Its Fluent and CFX solvers remain industry standards for aerospace, automotive, and energy users who need high-resolution, turbulence-resolved simulations. ANSYS is also embedding AI/ML tools across its suite and pushing deeper integrations into CAD, PLM, and digital twin ecosystems. Its strength? End-to-end capability. From pre-processing to result interpretation, ANSYS supports some of the most complex simulation workflows in the industry. Siemens Digital Industries Software Through its Simcenter portfolio, Siemens has carved out a powerful position — particularly in automotive and industrial machinery. Their CFD capabilities are tightly integrated with design and manufacturing platforms, making them ideal for engineering teams looking to close the loop from concept to production. Siemens also invests heavily in reduced-order models and real-time simulation for embedded use cases — for example, vehicle thermal management that adjusts dynamically during driving conditions. They’re betting big on model-based systems engineering — and CFD is part of that connected architecture. Dassault Systèmes Best known for its 3DEXPERIENCE platform, Dassault blends simulation with design collaboration. Its CFD solution, powered by SIMULIA , targets industries like aerospace, transportation, and life sciences — where simulation needs to be part of broader innovation chains. The platform’s strength lies in its ability to co-simulate structural, thermal, and fluid behaviors in a single environment — with an emphasis on cloud collaboration and immersive interfaces. For teams designing highly regulated products — like aircraft or implants — Dassault offers traceability, compliance, and precision in one package. Altair Engineering Altair’s AcuSolve and broader simulation suite are focused on flexibility and customization. They support a wide array of industries — from wind energy to marine hydrodynamics — and are known for strong meshing tools and GPU-enabled solvers. What sets Altair apart is its licensing model: users get access to a pool of tools across domains (not just CFD), which appeals to consultants and small firms juggling diverse projects. Altair is also expanding in Asia and Latin America through partnerships with universities and public sector design labs. SimScale A rising player in cloud-native simulation, SimScale is targeting accessibility. Its browser-based CFD platform is used by startups, SMEs, and academic teams who don’t have access to traditional HPC infrastructure. While not yet suited for deep multiphysics workflows, SimScale excels at iterative product design, early-stage validation, and training environments. Its user experience is geared toward engineers who need quick, visual feedback — not hours of solver tweaking. Their differentiator? Simplicity + scalability without upfront capital cost. ESI Group Though smaller, ESI Group has a strong foothold in virtual prototyping, especially for automotive crash and safety simulations. Its CFD solutions often integrate into broader digital mock-up environments — particularly for HVAC, thermal comfort, and interior airflow design. They position themselves as a niche but deep partner in vehicle and rail transit applications. OpenFOAM Ecosystem ( OpenCFD , CFD Direct, Community Forks) Though technically not a commercial vendor, OpenFOAM remains influential. It powers dozens of academic, industrial, and consulting workflows. The ecosystem around it — including cloud deployments and consultancy services — continues to grow. Its open architecture makes it a favorite for cutting-edge R&D and non-traditional applications like smart city airflow modeling or climate modeling . Competitive Takeaways: ANSYS and Siemens dominate high-fidelity, enterprise-grade CFD for regulated industries. SimScale and Altair are carving paths in accessibility and cost-effective deployment. OpenFOAM fuels academic innovation and flexible niche use cases. The next battleground? Solver speed, AI integration, and deployment flexibility. At the end of the day, CFD software isn’t judged only by its output. It’s judged by how quickly, easily, and collaboratively teams can get to the answers they need. 5. Regional Landscape and Adoption Outlook CFD adoption is growing globally — but not at the same pace or for the same reasons. In some regions, it’s all about precision engineering. In others, it’s about cost avoidance or sustainability compliance. Let’s break it down region by region. North America North America remains the innovation engine of the CFD market. The U.S., in particular, houses major players like ANSYS , Altair , and Rescale , along with leading aerospace, defense , and semiconductor customers. CFD is deeply embedded in R&D and design workflows — especially in industries with tight regulatory frameworks like aviation, healthcare, and energy. Public-private research initiatives from NASA, DARPA, and the Department of Energy continue to fund next-gen CFD tools. There’s also increasing crossover into academia, with universities training engineers directly on commercial-grade solvers. One growing trend in the U.S. is the integration of CFD into sustainability compliance — especially for HVAC, green buildings, and environmental modeling . Europe Europe is arguably the most mature CFD user base in terms of simulation standards and domain-specific expertise. Countries like Germany , France , and the UK have long used CFD across automotive, wind energy, and fluid process industries. The EU’s focus on emissions reduction, clean transportation, and industrial efficiency is pushing deeper simulation integration into the design phase — especially in electric vehicles and offshore wind. Software vendors like Siemens and Dassault Systèmes are based here, and that proximity matters — especially when tailoring tools for specific industrial sectors like rail transport or biomedical devices. In Scandinavia and Germany, there’s also rising use of CFD in smart city planning — simulating airflow, pollution dispersion, and thermal comfort in dense urban environments. Asia Pacific This is the fastest-growing CFD region, led by China, India, Japan, and South Korea. Growth is being fueled by: Expanding local manufacturing and design ecosystems Government-backed R&D in aerospace, defense , and energy Increasing adoption of cloud-based CFD among startups and SMEs In China , domestic CFD development is accelerating, but U.S. and European tools still dominate in high-end applications. Local demand is high in EV design, smart grid simulation, and infrastructure airflow modeling . India is seeing a boom in outsourced CFD consulting services, thanks to a strong base of engineering talent. Cloud CFD adoption is rising in Indian edtech and medtech startups as well. Japan and South Korea remain leaders in electronics cooling and thermal design, particularly for semiconductors and high-performance computing — two segments that are driving precision CFD adoption. Latin America Still a nascent market, but one with potential. Brazil and Mexico are early adopters — primarily in aerospace, oil & gas, and energy infrastructure. CFD is mostly used through engineering service providers or via university partnerships. Large-scale CFD deployments are still rare, but the region is attracting pilot programs and vendor expansion — especially for cloud simulation platforms that reduce CapEx . As Latin American cities grapple with air quality and climate resilience, CFD is starting to play a small role in public infrastructure planning. Middle East and Africa (MEA) Adoption here is highly concentrated. UAE and Saudi Arabia are the two hotspots — driven by massive infrastructure projects, defense modernization, and smart city development. CFD is being used in: Mega construction (airflow, heat islands) Industrial planning (fluid processing, HVAC design) Clean energy (solar cooling, wind farm siting) Africa , however, remains largely untapped. There are small signs of CFD use in mining, HVAC, and university-led engineering projects — but the market is fragmented. Regional Summary North America and Europe are mature and solver-intensive — CFD is part of the design DNA. Asia Pacific is scaling rapidly, both in consumption and production of CFD tools. LAMEA offers white-space opportunities, especially for cloud-native and consulting-based models. Ultimately, CFD growth in each region isn’t just about tech adoption. It’s about talent pipelines, regulatory needs, and whether design teams are empowered to simulate early — not just validate late. 6. End-User Dynamics and Use Case CFD tools are used across a surprisingly wide range of environments — from elite aerospace labs to high school classrooms using browser-based solvers. Each type of end user has different expectations, and the way CFD delivers value varies depending on technical depth, budget, and business goals. Large OEMs and Industrial Enterprises This is the traditional stronghold of CFD. Companies in automotive , aerospace , energy , and shipbuilding have entire departments built around simulation-driven design. These users typically run high-fidelity solvers on-premise, rely on custom workflows, and prioritize solver accuracy over accessibility. For these firms, CFD is embedded into long product cycles. It’s used not just for design validation but also for regulatory submissions, failure analysis, and digital twin creation. Example: An EV maker might simulate battery thermal behavior under extreme conditions, varying hundreds of parameters before building a single physical prototype. Engineering Service Providers and Consultants Mid-sized simulation firms and consulting outfits use CFD to provide external support to manufacturers who don’t have in-house simulation capabilities. Their challenge? Balancing solver fidelity with fast turnaround. These firms often run multi-physics solvers across sectors — for example, modeling wind tunnel behavior one day and HVAC airflow the next. Licensing flexibility, GPU acceleration, and team collaboration features matter more than advanced solver depth. They also serve as testbeds for emerging CFD vendors trying to penetrate new verticals. Academic and Research Institutions Universities are the unsung drivers of CFD innovation. They build new solvers, test turbulence models, and validate fluid behavior at experimental scales. Most academic labs rely on open-source platforms like OpenFOAM , SU2, or custom-built solvers tailored to niche use cases. CFD is used here for a wide range of research: microfluidics, combustion studies, blood flow, pollutant dispersion, and even food processing. In many countries, especially in Asia and Latin America, university labs double as simulation centers for startups and local industry — offering shared access to tools and expertise. Startups and SMEs This group is expanding quickly. CFD was once too expensive or complex for early-stage companies — but cloud-native platforms, AI pre-processing, and guided interfaces have changed that. Industries like consumer hardware , electronics , biotech , and even agritech are tapping into lightweight CFD for fast iteration. These firms don’t need full-blown solvers — they want speed, simplicity, and reasonable accuracy to reduce trial-and-error costs. Insight: Some cloud CFD tools now offer ‘simulation recipes’ — pre-built templates for common use cases like PCB cooling or pump cavitation — which let even non-specialists run simulations in minutes. Construction, HVAC, and Built Environment Firms While not traditional CFD users, this group is emerging fast — especially in response to green building standards and indoor air quality regulations. Architects and HVAC designers use CFD to simulate airflow, occupant comfort, and thermal zoning. The COVID-19 pandemic further boosted demand for airflow modeling in public spaces. Use Case Highlight A mid-size biomedical startup in Switzerland needed to simulate how a stent affected blood flow in cerebral arteries. Traditional CFD setups were too slow and expensive — each iteration took 18 hours and required manual mesh refinement. They switched to a GPU-accelerated, cloud-based platform with AI-powered mesh optimization. Simulation time dropped to under 2 hours. They also built a digital library of flow results that regulatory teams used for pre-clinical evidence. The outcome? Faster design lock, cleaner documentation, and a 6-month time-to-market advantage. Bottom line: CFD use cases are multiplying because the barriers to entry are dropping . Vendors who meet each segment’s unique needs — from enterprise-grade depth to SME-friendly speed — will lead the next growth wave. 7. Recent Developments + Opportunities & Restraints Recent Developments (Last 2 Years) The CFD market has seen a steady stream of product upgrades, strategic alliances, and AI-led breakthroughs over the past 24 months. A few developments stand out for their potential to reshape the space: ANSYS introduced a new AI-assisted turbulence modeler in 2024 that automatically tunes wall functions and mesh refinement for complex aerodynamic flows — particularly useful for hypersonic and space applications. SimScale launched its next-gen cloud-native platform in 2023, offering fully integrated thermal, structural, and fluid simulations in a no-code interface, targeting hardware startups and product designers. In 2023, Altair rolled out CFD GPU acceleration support across its AcuSolve platform, cutting simulation time by over 60% for large-scale problems like wind farm optimization and turbine blade cooling. Dassault Systèmes expanded SIMULIA’s multi-scale modeling tools in 2024, enabling hybrid CFD-structural workflows for medical devices and drone propulsion systems. CFD Direct , a key contributor to OpenFOAM , released a version supporting native parallel GPU solvers and advanced volume-of-fluid models, paving the way for more accessible multiphase flow simulation. Opportunities Expansion in Electronics Cooling and Semiconductor Design As chipsets get denser and thermal budgets shrink, CFD is now essential to ensure safe and efficient thermal dissipation — especially in 5G infrastructure, edge computing, and AI data centers . This segment is poised for major growth, especially in Asia and North America. AI-Augmented Simulation for Rapid Design Iteration Combining AI with CFD enables the creation of surrogate models that dramatically speed up exploration of design spaces. For sectors like automotive and medtech , where time-to-market matters, this fusion allows engineers to simulate thousands of design permutations in Restraints High Software and Licensing Costs CFD platforms require expensive licensing models and frequent updates, which make them financially challenging for startups and smaller enterprises. This restricts adoption mainly to large organizations with bigger R&D budgets. Shortage of Skilled Professionals The complexity of CFD tools demands strong expertise in mathematics, physics, and engineering principles. A limited talent pool slows adoption across industries, as many organizations cannot fully leverage the technology. Computational Infrastructure Requirements High-fidelity CFD simulations consume enormous processing power, often requiring high-performance computing clusters. Small and mid-sized firms without such infrastructure face limited simulation capabilities and must rely on simplified models. Validation and Reliability Concerns CFD results still need experimental validation to ensure accuracy. Discrepancies between simulated and real-world performance create hesitation in safety-critical sectors like aerospace, defense, and automotive. Data Security Challenges in Cloud-Based Solutions With the growing shift toward cloud-enabled CFD, concerns over data privacy and intellectual property theft arise. Industries handling sensitive designs, such as aerospace and automotive, remain cautious about fully adopting cloud platforms. 7.1. Report Coverage Table Report Attribute Details Forecast Period 2024 – 2030 Market Size in 2024 USD 2.2 Billion Revenue Forecast in 2030 USD 3.9 Billion Overall Growth Rate CAGR of 9.6% (2024–2030) Base Year for Estimation 2024 Historical Data 2019 – 2023 Unit USD Million, CAGR Segmentation By Deployment, By Application, By End User, By Region By Deployment On-Premise, Cloud-Based By Application Aerospace, Automotive, Energy, Electronics, Healthcare By End User OEMs, Consultants, Academic, SMEs By Region North America, Europe, Asia-Pacific, Latin America, MEA Country Scope U.S., Germany, China, India, Japan, UAE, Brazil Market Drivers - Rise in simulation-led design - Surge in electronics and medtech thermal needs - Cloud CFD democratization Customization Option Available upon request Frequently Asked Question About This Report Q1. How big is the computational fluid dynamics market? The global computational fluid dynamics (CFD) market is estimated to be worth USD 2.2 billion in 2024. Q2. What is the expected CAGR for the CFD market during the forecast period? The CFD market is projected to grow at a CAGR of 9.6% between 2024 and 2030. Q3. Who are the key players in the computational fluid dynamics market? Leading players include ANSYS, Siemens Digital Industries Software, Dassault Systèmes, Altair Engineering, SimScale, and ESI Group. Q4. Which region leads the CFD market? North America remains the largest CFD market, with significant adoption in aerospace, defense, and electronics. Q5. What are the major drivers for CFD market growth? Growth is fueled by AI-integrated simulation, expanding applications in electronics and healthcare, and cloud democratization of high-fidelity tools. Table of Contents for Computational Fluid Dynamics Market Report (2024–2030) Executive Summary Market Overview CFD Market Attractiveness by Deployment, Application, End User, and Region Strategic Takeaways from Key Executives Market Size Forecast (2024–2030) Summary of Core Segments and Growth Drivers Market Share Analysis Revenue Share by Key Players (2024 & 2030) Market Share Breakdown by Application Segment Market Share Breakdown by Deployment Mode Investment Opportunities in the CFD Market High-Growth Verticals (Electronics Cooling, MedTech, Smart Infrastructure) Emerging Use Cases for AI-Enabled CFD Strategic Expansions and Vendor Partnerships Market Introduction Definition, Scope, and Relevance of CFD in 2024–2030 Market Structure and Value Chain Overview of Technology Migration and Adoption Barriers Research Methodology Data Triangulation and Forecasting Logic Primary and Secondary Data Sources Inference Models for Market Sizing Market Dynamics Key Market Drivers Major Restraints and Operational Barriers Technology Enablers: Cloud, AI, and GPUs Regulatory Factors and Standards Adoption Global CFD Market Breakdown By Deployment On-Premise Cloud-Based By Application Aerospace & Defense Automotive & Transportation Energy & Power Generation Electronics & Semiconductors Healthcare & Life Sciences By End User OEMs Engineering Consultants Academic & Research Institutions Startups & SMEs By Region North America Europe Asia-Pacific Latin America Middle East & Africa Regional Market Analysis North America U.S., Canada Europe Germany, UK, France, Rest of Europe Asia-Pacific China, India, Japan, South Korea, Rest of APAC Latin America Brazil, Mexico, Rest of LATAM Middle East & Africa UAE, Saudi Arabia, South Africa, Rest of MEA Key Players and Competitive Landscape ANSYS Siemens Digital Industries Software Dassault Systèmes Altair Engineering SimScale ESI Group CFD Direct / OpenFOAM Ecosystem Vendor Positioning Matrix (2024 vs. 2030) Appendix Abbreviations & Definitions Reference Data and Source List Methodological Notes